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منابع مشابه
Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole.
A candidate antitumor agent, 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203), was empirically discovered through the National Cancer Institute's Anticancer Drug Screen from a unique growth inhibitory-response profile, indicating a novel mechanism of action. 5F-203 activates the CYP1 family of cytochrome P450, involving aryl hydrocarbon receptor translocation into the nucleus. To chara...
متن کاملAnti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3
Breast cancer is a major public health problem worldwide in women and existing treatments are not adequately effective for this deadly disease. microRNAs (miRNAs) regulate the expression of many target genes and play pivotal roles in the development, as well as in the suppression of many cancers including breast cancer. We previously observed that miR-203 was highly upregulated in breast cancer...
متن کاملA Bmi1-miRNAs Cross-Talk Modulates Chemotherapy Response to 5-Fluorouracil in Breast Cancer Cells
The polycomb group transcriptional modifier Bmi1 is often upregulated in numerous cancers and is intensely involved in normal and cancer stem cells, and importantly is as a prognostic indicator for some cancers, but its role in breast cancer remains unclear. Here, we found Bmi1 overexpression in 5-Fu (5-fluorouracil)-resistant MCF-7 cells (MCF-7/5-Fu) derived from MCF-7 breast cancer cells, MDA...
متن کاملMechanistic Assessment of DNA Ligase as an Antibacterial Target in Staphylococcus 1 aureus 2 3 Steven
Mechanistic Assessment of DNA Ligase as an Antibacterial Target in Staphylococcus 1 aureus 2 3 Steven D. Podos, Jane A. Thanassi, and Michael J. Pucci* 4 Achillion Pharmaceuticals, New Haven, CT 06511 5 6 7 Running title: DNA Ligase as an antibacterial target 8 9 *Corresponding author 10 Mailing address: 11 Achillion Pharmaceuticals 12 300 George Street 13 New Haven, CT 06511 14 Phone: (203) 62...
متن کاملCo-culture of early cattle embryos to the blastocyst stage with oviducal tissue or in conditioned medium.
In Exp. 1, 5-8-cell embryos from superovulated cattle were co-cultured with oviducal tissue suspended in Ham's F10 + 10% fetal calf serum (F10FCS) or in F10FCS alone. After 4 days, the proportion of embryos developing into compact morulae or blastocysts was greater (P less than 0.005) in co-culture (38/82; 46%) than in F10FCS (1/27; 4%). In Exp. 2, a solution of collagenase, trypsin, DNAse and ...
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